Soma · Disease Ontology
Morbus is the human disease ontology, taxonomy, and model inside Persona. It organizes disease knowledge without assuming that every inherited clinical category is a clean natural kind — working from the hypothesis that many diseases are better understood as intersecting processes than as single objects.
15 interactive exemplars below · shareable via URL hash
Rather than starting from organ systems or specialty boundaries, Morbus organizes disease first by whether it is defined by a relatively identifiable cause, by emergent physiological dysregulation over time, or by both at once.
Pathology is chiefly organized around a relatively identifiable initiating cause.
Physical injury
Deficiency
Chemical exposure
Infectious disease
Hereditary disease
Pathology emerges from complex dysregulation of physiological systems over time.
Cardiovascular
Metabolic / endocrine
Neurological
Degenerative
Neoplastic
Immunological / inflammatory
Cause and physiology are both essential; one disease may belong to multiple explanatory layers.
Infection plus host response
Gene plus physiology
Environment plus regulation
Immune plus tissue ecology
Treatment effect
Beneath the top-level frame, Morbus separates the layers that get collapsed when a disease is treated as one object. A single condition is built from several of these primitives at once.
A condition treated as a recognizable, nameable whole.
A co-occurring cluster of features without a single settled cause.
The unfolding mechanism by which function is disrupted.
The initiating cause or causes that set the process in motion.
A predisposing condition that raises the probability of disease.
The structural change visible at the level of tissue.
The pathway, mutation, or signalling change underneath.
The characteristic immune response or dysregulation involved.
Failure of epithelial, vascular, or other protective barriers.
The microbial community whose shifts shape the condition.
A downstream condition arising from the primary disease.
Change in the disease produced by intervention.
Harm caused by medical care itself.
The condition as felt and narrated by the person living it.
The working hypothesis of Morbus is that one condition is simultaneously anatomical, molecular, immunological, developmental, ecological, environmental, and social. Explore how key human diseases decompose along each axis rather than being forced into a single legacy category.
15 exemplar diseases · 9 axes each
A relapsing-remitting inflammatory condition of the gastrointestinal tract, emerging from polygenic risk, barrier disruption, and dysregulated host immune response to gut microbiota.
Simulate how a computational agent queries the database registries of the Digital Halo to aggregate physiological evidence. Click a tab to select a database.
Simulated API Request URL
Querying literature database for clinical trials and review articles linking NOD2 mutations to Crohn's disease susceptibility.
Knowledge Synthesis & Findings
{
"esearchresult": {
"count": "1485",
"retmax": "3",
"idlist": ["38128312", "37992019", "37554318"],
"translationset": [
{ "from": "inflammatory bowel disease", "to": "\"inflammatory bowel diseases\"[MeSH Terms] OR \"inflammatory bowel disease\"[All Fields]" }
]
}
}Existing nosologies are treated as reference mappings rather than the native Morbus hierarchy. ICD-11 in particular is a public reporting crosswalk — a way to translate out, not the structure to organize around.
Many diseases are better understood as intersecting processes rather than single objects. Morbus supports plural classification: one condition may be simultaneously anatomical, molecular, immunological, developmental, ecological, environmental, and social.